Evidence-based longevity and healthspan research
M Matt Kaeberlein Video Summary · March 16, 2026 View Full Protocol → Key Takeaways Monitor soft plaque: Even if you don’t have calcified plaque, soft plaque is more dangerous and can rupture, leading to a heart attack. Prioritize heart health: Focus on maintaining clear arteries by reducing fatty plaque buildup to prevent atherosclerosis. Understand…
J Jason Fung Video Summary · March 16, 2026 View Full Protocol → Key Takeaways Focus on food quality, not just calories – Processed foods (like Frappuccinos/cookies) spike insulin more than whole foods (beef/salads) even at the same calorie count Prioritize insulin control – High-insulin foods (sugars/refined carbs) signal fat storage and increase hunger soon…
C Chris Williamson Video Summary · March 16, 2026 Key Takeaways Limit social media use – Excessive exposure to unrealistic sexual content can distort expectations and reduce real-life intimacy. Prioritize in-person connections – Replace digital interactions with face-to-face time to rebuild social and sexual confidence. Address mental health proactively – Anxiety and depression are major…
R Rhonda Patrick Video Summary · March 16, 2026 View Full Protocol → Key Takeaways Exercise regularly: Combine cardiovascular exercise, high-intensity workouts, and resistance training to help regulate cholesterol levels. Follow a Mediterranean diet: Limit saturated fat intake and focus on heart-healthy foods. Manage stress: Chronic stress raises cholesterol levels, so practice stress-reducing techniques like…
D Dr. Karan Video Summary · May 11, 2026 View Full Protocol → Key Takeaways Chew food thoroughly (around 20 times per bite) to improve digestion, nutrient absorption, and satiety signaling. Practice diaphragmatic breathing to strengthen the esophageal valve and reduce acid reflux. Avoid mouthwash with alcohol or antiseptics, as it disrupts the beneficial oral…
D Dr. Karan Video Summary · March 16, 2026 View Full Protocol → Key Takeaways Psychedelics like psilocybin, LSD, and DMT show promise in treating treatment-resistant depression, with some studies indicating architectural changes in the brain. SSRIs (selective serotonin reuptake inhibitors) work for about 70% of people with depression, but 30% are treatment-resistant and may…
R Rhonda Patrick Video Summary · March 16, 2026 View Full Protocol → Key Takeaways Reduce visceral fat to lower chronic inflammation, which harms cognition and mood. Monitor inflammation markers regularly if you have high visceral fat to track health impact. Exercise regularly to decrease visceral fat and its inflammatory effects. Adopt anti-inflammatory dietary habits…
M Modern Healthspan Video Summary · March 16, 2026 View Full Protocol → Key Takeaways Exercise regularly to support brain health as you age, as it helps repair the blood-brain barrier. Focus on activities that improve cardiovascular health, as they may boost the liver’s production of GPLD1, aiding brain protection. Maintain consistency in physical activity…
M Matt Kaeberlein Video Summary · March 16, 2026 View Full Protocol → Key Takeaways Download the 2026 Longevity March Madness Tournament bracket at www.optispan.life/longevity-bracket to participate. Submit your completed bracket before March 19th for a chance to win prizes and claim the top spot. Vote in real-time on Instagram and X throughout the tournament….
M Max Lugavere Video Summary · March 16, 2026 View Full Protocol → Key Takeaways Leverage AI to access global medical knowledge and clinical experience beyond your local doctor. Combine AI insights with professional medical advice for a more informed healthcare approach. Educate yourself using AI tools to better understand and manage your health. Notable…
G Gabrielle Lyon Video Summary · March 17, 2026 View Full Protocol → Key Takeaways Switch to high-intensity interval training (HIIT) for efficient metabolic health improvements. Aim for 10-15 minutes of vigorous exercise sessions instead of longer, moderate workouts. Boost mitochondrial capacity through HIIT to enhance metabolic flexibility. Focus on VO2 Max improvements, achievable through…
S Siim Land Video Summary · May 10, 2026 View Full Protocol → Key Takeaways Move every 30-60 minutes for at least 1-3 minutes to improve blood sugar control and overall health. Combine walking and squatting throughout the day to activate large muscles and improve circulation. Walking stimulates the soleus muscle, which helps pump blood…
