Longevity Notes
The longevity intelligence platform. Evidence-rated supplement protocols from the world’s top health experts — compared, tracked, and updated as they evolve.
35+
Supplements analyzed
12
Expert protocols
100+
Sources cited
6
Research deep dives
Expert Supplement Protocols
PA
Peter Attia, MD
Physician · Medicine 3.0
Conservative
Exercise-first, supplements as backup
AH
Andrew Huberman, PhD
Neuroscientist · Stanford
Moderate
Neuroscience-driven protocol with cycling
DS
David Sinclair, PhD
Geneticist · Harvard
Aggressive
15+ compounds including Rx drugs
GB
Gary Brecka
Biohacker · MTHFR specialist
Biohacker
Methylation-focused with gene testing approach
BJ
Bryan Johnson
Entrepreneur · Project Blueprint
Maximalist
100+ daily pills, $2M/year protocol
RP
Rhonda Patrick, PhD
Biomedical Scientist · FoundMyFitness
Biomarker-driven
Tests and adjusts doses by blood work
PD
Peter Diamandis, MD
Futurist · XPRIZE Founder
Aggressive
Tech-optimist — aggressive stack with rapamycin
MK
Matt Kaeberlein, PhD
Aging Scientist · Optispan
Minimal
4 supplements only — “foundations over fluff”
MH
Mark Hyman, MD
Functional Medicine · Cleveland Clinic
Functional
Root-cause approach with NMN and senolytics
BS
Brad Stanfield, MD
GP · Evidence-Based YouTuber (240K+)
Skeptical
3 core supplements, transparent about what he stopped
SL
Siim Land
Author · Biohacker · #4 Rejuvenation Olympics (350K+)
Foundation-first
Glycine, collagen, omega-3. $80–120/mo total
GL
Dr. Gabrielle Lyon, DO
Physician · Muscle-Centric Medicine® · NYT Bestseller
Muscle-centric
Protein-first — creatine, urolithin A, resistance training
Longevity Research Deep Dives
Rapamycin
The most studied longevity drug — from organ transplants to lifespan extension
Metformin
The diabetes drug turned longevity candidate — TAME trial and beyond
Intermittent Fasting
Caloric timing, autophagy, and longevity pathway activation
Caloric Restriction
The oldest longevity intervention — from lab worms to CALERIE trials
Senolytics
Clearing zombie cells — fisetin, dasatinib, quercetin and healthspan
Clinical Trials
Active longevity research you can follow and participate in
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Longevity Notes is an independent research platform. We are not affiliated with any supplement company. Protocol pages are based on publicly shared information (podcasts, YouTube, books, interviews) and are updated as experts change their stacks. About our research process →