Rhonda Patrick: 10 Supplements Everyone Over 65 Should Be Taking (Don’t Skip #3)

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Peer-Reviewed Research
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Rhonda Patrick

Video Summary · February 3, 2026

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Key Takeaways

  • Vitamin D: Essential for older adults (65+), especially since sun exposure declines. Aim for sufficient daily supplementation.
  • Omega-3: Target an 8%+ Omega-3 index with 1.5-2g daily to support brain and heart health.
  • Multivitamin: Prioritize one with lutein & zeaxanthin to delay brain aging and support eye health.
  • Magnesium: Critical for DNA repair and energy. Supplement 300-400mg/day (men) or ~300mg/day (women).
  • Creatine: 5g/day minimum (10g preferred) for muscle/brain function, especially under stress or aging.

Supplements & Protocols Mentioned

  • Vitamin D: Daily dose (amount unspecified; prioritize based on sun exposure and blood levels).
  • Omega-3: 1.5-2g/day to reach 8%+ Omega-3 index.
  • Multivitamin: Centrum Silver or Pure Encapsulations One (with lutein/zeaxanthin).
  • Magnesium: 300-400mg/day (men), ~300mg/day (women).
  • Melatonin: 1.5-3mg/night, taken 2+ hours before bedtime for age-related decline.
  • Creatine monohydrate: 5-10g/day for muscle/brain support.
  • Ubiquinol: For mitochondrial/heart health (dosage unspecified).
  • Avmacol: Sulforaphane supplement (dosage unspecified).

Notable Quotes

“Multivitamins have now been shown in three large randomized controlled trials… delayed global brain aging by 2.1 years.”

“Creatine at doses of 10 grams a day probably [helps] in the background of any type of brain stress.”

Bottom Line

Prioritize Vitamin D, Omega-3, a quality multivitamin, magnesium, and creatine for longevity. Add melatonin if sleep declines, and consider ubiquinol/sulforaphane for cellular health.

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Medical Disclaimer

This article is for informational purposes only and does not constitute medical advice. The research summaries presented here are based on published studies and should not be used as a substitute for professional medical consultation. Always consult a qualified healthcare provider before making any changes to your health regimen.

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