Rhonda Patrick: This Supplement Is the FASTEST Way to Boost NAD

Key Takeaways

• Take nicotinamide riboside (NR) for NAD boosting – it’s the most effective oral precursor that can enter cells directly.
• Avoid oral NAD supplements – they break down before reaching cells and are inefficient.
• Consider nicotinamide (a form of vitamin B3) for cancer prevention benefits, especially for skin cancer risk reduction.
• Be cautious with nicotinic acid (another B3 form) – high doses cause uncomfortable flushing.
• Skip NMN supplements – they convert back to NR before entering cells, making NR the more direct option.

Supplements & Protocols Mentioned

• Nicotinamide riboside (NR) – Premium NAD precursor with extensive safety data
• Nicotinamide – Safe, cancer-preventive form of vitamin B3 found in multivitamins
• Nicotinic acid – Causes flushing at NAD-boosting doses (sometimes used for lipid regulation)
• IV NAD therapy – Painful and triggers immune response (oral NR is preferred)
• IV NR therapy (Niagen Plus) – Emerging option with potential for higher tissue delivery

Notable Quotes

“NR is probably the kind of premium NAD precursor in the sense that the NR kinase pathway gets upregulated in a lot of conditions of metabolic stress.”

“Why not just take the NR? NR is the most safety-tested NAD booster on the market.”

Bottom Line

For effective NAD boosting, take oral nicotinamide riboside (NR) supplements – they’re safer and more efficient than NAD, NMN, or other precursors. Avoid oral NAD supplements as they break down before reaching cells.

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