Matt Kaeberlein: Reacts to Round 1 of Longevity March Madness (Live Results Reveal)

Key Takeaways

• Not smoking beats Italian grandpa lifestyle (88.8% vote) as top longevity lifestyle choice
• Mediterranean diet crushes ketogenic diet (93% vote) for optimal nutrition
• Strength training dominates moderate alcohol consumption (97% vote) for health benefits
• Rapamycin overwhelmingly preferred (95.1% vote) over Cerebrolysin in geroscience category
• GLP-1 agonists beat low-dose aspirin (88.7% vote) despite limited healthy population data

Supplements & Protocols Mentioned

• Metformin – lost to PCSK9 inhibitors (75% vote)
• Spermidine – lost to epigenetic reprogramming (30.6% vote)
• Glycine – beat Alpha-Ketoglutarate (57.4% vote)
• NAD precursors – lost to Urolithin A (41% vote)
• Dasatinib + Quercetin – narrowly lost to TRIM protocol (49.2% vote)

Notable Quotes

“The data is pretty mixed for Metformin… PCSK9 inhibitors have really no good evidence for a healthy population at this point”

“Rapamycin wins with a blowout – 95.1% versus 4.9%”

Bottom Line

Focus on evidence-backed interventions like not smoking, Mediterranean diet, strength training, and Rapamycin while being cautious about emerging therapies with limited human data.

Watch the Full Video