Matt Kaeberlein: Longevity Doctors Rank the Most Hyped Supplements (AMA with Dr. Kaeberlein and Dr. Byrne)

Key Takeaways

• Resveratrol claims are overstated: It does NOT potently activate sirtuins, and sirtuins are NOT master regulators of longevity.
• Creatine is kidney-safe: Elevated creatinine levels from creatine supplementation do NOT indicate kidney dysfunction.
• Monitor lithium if taking SGLT2 inhibitors: These drugs cause 20-40% lithium loss; consider dose adjustment (e.g., increasing from 5mg to 10mg).
• Natural ≠ better: Be rational about supplements vs pharmaceuticals (e.g., berberine vs metformin, red yeast rice vs statins).
• Taurine evidence is early-stage: While intriguing for longevity, human benefits remain unproven.

Supplements & Protocols Mentioned

• Creatine: Safe for kidney health (even studied in dialysis patients).
• Lithium: Dose may need adjustment (5mg → 10mg) if taking SGLT2 inhibitors.
• CoQ10: Statins reduce endogenous production, but clinical benefits are unclear.
• Taurine: Early longevity evidence in animals, unproven in humans.
• Astaxanthin: Preclinical promise but limited human data on hard outcomes.
• Magnesium, Omega-3s, Vitamin D: Personal staples for longevity.

Notable Quotes

“Natural is better than pharmaceutical… but when it comes down to the actual molecule, try to be completely rational about it.”

Bottom Line

Focus on supplements with strong evidence (magnesium, omega-3s, vitamin D), ignore overstated claims (resveratrol), and adjust medications like lithium if needed. Approach “natural” alternatives with skepticism.

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