Evidence-based longevity and healthspan research
S Siim Land Video Summary · March 4, 2026 View Full Protocol → Key Takeaways Hemoglobin A1c: Aim for 4.5-5.2% to minimize glycation damage and mortality risk. Above 5.5% increases cardiovascular risk. Triglycerides: Keep below 50 mg/dL (0.6 mmol/L) for optimal metabolic health. Above 150 mg/dL signals high heart disease risk. hs-CRP: Target
R Rhonda Patrick Video Summary · March 4, 2026 View Full Protocol → Key Takeaways Vitamin D3 – Give children 600-1000 IU daily (400-600 IU for under 4s). Use drops like Carlson’s or Thorne D3+K2. Omega-3s – Supplement with 250-500mg EPA/DHA daily. Use flavored liquids (Carlson’s berry) or high-quality capsules (Pure Encapsulations). Multivitamin – Use…
R Rhonda Patrick Video Summary · March 4, 2026 View Full Protocol → Key Takeaways Magnesium deficiency affects 60% of Americans due to insufficient dark leafy greens consumption. Magnesium is required for DNA repair – critical to prevent mutations that cause cancer over decades. Oxidative damage from metabolism constantly damages DNA – magnesium-dependent repair processes…
D Dr. Karan Video Summary · March 4, 2026 View Full Protocol → Key Takeaways Avoid unverified supplements: Many products on the market, especially on Amazon, are not third-party tested and may be contaminated or ineffective. Simplify your supplement stack: Focus on a few core supplements you know you need, rather than taking excessive amounts….
S Siim Land Video Summary · May 20, 2026 View Full Protocol → Key Takeaways Take 1g/day of omega-3s to slow biological aging by 3-4 months over 3 years (based on RCT data). Combine omega-3s with vitamin D and exercise for additional anti-aging benefits (1-2 months further reduction). Use omega-3s for heart health – they…
M Matt Kaeberlein Video Summary · May 20, 2026 View Full Protocol → Key Takeaways Avoid unapproved peptides and drugs in longevity and functional medicine circles due to lack of quality safety and efficacy data. Be cautious with popular wellness trends that lack rigorous scientific backing. Question the safety and efficacy of any drug or…
M Mark Hyman Video Summary · May 21, 2026 View Full Protocol → Key Takeaways Recognize subtle symptoms like fatigue, constipation, dry skin, cracked nails, thinning outer eyebrows, low mood, or reduced libido – these may indicate autoimmune thyroid issues. Don’t dismiss digestive issues like irritable bowel as “normal” – they often signal underlying inflammation….
M Matt Kaeberlein Video Summary · May 20, 2026 View Full Protocol → Key Takeaways Avoid mitochondrial/metabolic activators and exercise mimetics without robust safety data Exercise caution with any interventions targeting cellular powerhouses (mitochondria) Prioritize compounds with established safety profiles over experimental metabolic boosters Notable Quotes “In general, mucking around with the powerhouses of the…
D Dr. Karan Video Summary · May 20, 2026 View Full Protocol → Key Takeaways Dopamine is a memory molecule – Your brain remembers where you got rewarding experiences (food, screens, etc.) through dopamine pathways. Limit overstimulation – Excessive screen time and instant gratification (sugar, phones) may contribute to earlier dementia risk via dopamine-related plaque…
M Matt Kaeberlein Video Summary · May 20, 2026 View Full Protocol → Key Takeaways Assess your understanding of the risks before considering experimental medications or drugs. Verify information thoroughly and avoid relying solely on random internet sources for informed consent. Weigh potential catastrophic side effects (e.g., cataracts, stroke, death) against the benefits, especially for…
R Rhonda Patrick Video Summary · May 20, 2026 View Full Protocol → Key Takeaways Wake up before dawn (4:30 AM) to align with the Brahma muhurta period, enhancing productivity, creativity, and focus. Work out daily (4:45 – 5:45 AM), focusing on zone 2 cardio, zone 3 HIIT, and resistance training to maintain joint health…
R Rhonda Patrick Video Summary · May 20, 2026 View Full Protocol → Key Takeaways Avoid purchasing peptides from unverified sources, especially those originating from China, due to contamination risks. Consult a physician for legitimate peptides like GLP-1, which can be sourced from reputable US compounding pharmacies. Be cautious with widely promoted peptides like BPC-157,…
