Matt Kaeberlein: 3HAA: The Longevity Molecule You’ve Never Heard Of
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Peer-Reviewed Research
Peer-Reviewed Research
M
Matt Kaeberlein
Video Summary · April 20, 2026
Key Takeaways
- 3HAA (3-Hydroxyanthranilic Acid) extends lifespan in worms by 25-30% and in mice by ~15%.
- Mechanisms include improving intestinal health, enhancing microbiome interactions, and activating stress response pathways.
- In mice, 3HAA shows sex-specific lifespan effects: males benefit more from dietary supplementation, females from genetic modulation.
- Currently, 3HAA is not available as a supplement due to historical concerns about carcinogenicity, but those concerns have been reassessed.
Bottom Line
Continue following research on 3HAA, but avoid supplementation until further clinical studies confirm its safety and efficacy in humans.
Explore More
- Matt Kaeberlein’s Full Protocol — supplements, dosages, and daily routine
- Compare All Protocols — side-by-side protocols
Watch the Full Video
Medical Disclaimer
This article is for informational purposes only and does not constitute medical advice. The research summaries presented here are based on published studies and should not be used as a substitute for professional medical consultation. Always consult a qualified healthcare provider before making any changes to your health regimen.
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