Rhonda Patrick: The best time of day to take creatine

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Peer-Reviewed Research
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Rhonda Patrick

Video Summary · February 18, 2026

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Key Takeaways

  • Take creatine in the morning or early afternoon for optimal brain benefits.
  • Avoid taking creatine in the evening – some report sleep disturbances.
  • Last dose of creatine should ideally be before ~2:00 PM.

Notable Quotes

“I do think that timing matters. You do want to get it more in the morning, afternoon, so you don’t want to be taking it necessarily later in the evening time.”

Bottom Line

Take creatine before 2:00 PM for cognitive benefits and to avoid potential sleep issues.

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Medical Disclaimer

This article is for informational purposes only and does not constitute medical advice. The research summaries presented here are based on published studies and should not be used as a substitute for professional medical consultation. Always consult a qualified healthcare provider before making any changes to your health regimen.

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