Evidence-based longevity and healthspan research
D Diary of a CEO Video Summary · April 20, 2026 Key Takeaways Pulse supplements like Resveratrol and Metformin/Berberine – take every other day instead of daily for better longevity effects Use saunas regularly (preferably dry sauna over steam) – linked to reduced heart disease and mortality Combine fasting (skipping meals) with intense aerobic exercise…
G Gabrielle Lyon Video Summary · April 20, 2026 View Full Protocol → Key Takeaways Compare expert perspectives – Seek out both traditional and holistic viewpoints on health decisions like hormone replacement therapy (HRT). Host balanced discussions – Invite experts with opposing views (e.g., pharmaceutical vs. bioidentical HRT) to present evidence. Empower personal choice –…
M Mark Hyman Video Summary · April 20, 2026 View Full Protocol → Key Takeaways Get comprehensive health testing beyond standard care (like Function Health) to detect hidden issues early. Request full-body MRI scans if you have risk factors or unexplained symptoms. Advocate for your own health – push for diagnostics if something feels off….
M Matt Kaeberlein Video Summary · April 20, 2026 View Full Protocol → Key Takeaways Study long-lived species like giant tortoises to understand biological mechanisms of slow aging. Focus on cellular maintenance – slower metabolism and enhanced protein/DNA repair systems contribute to longevity. Research cancer resistance – exceptional species evolved superior protective mechanisms against age-related…
S Siim Land Video Summary · April 20, 2026 View Full Protocol → Key Takeaways Leverage placebo mindset – Expect strength gains before workouts to push harder and recruit more muscle fibers. Boost dopamine pre-workout – Use anticipation of performance (e.g., visualizing PRs) to enhance motivation and effort. Reframe pain perception – Expect reduced discomfort…
B Bryan Johnson Video Summary · April 7, 2026 View Full Protocol → Key Takeaways Aim for 6 hours of exercise per week: Split into 3 sessions of cardio and 3 sessions of strength training. Include 150 minutes of zone 2 cardio and 75 minutes of vigorous exercise (like HIIT or sprints) weekly to reduce…
M Michael Greger Video Summary · April 20, 2026 View Full Protocol → Key Takeaways Avoid ultra-processed foods, even if they appear low in calories, fat, sugar, or salt, as they often contain harmful additives like caramel color, aspartame, and phosphoric acid. Limit consumption of artificial food colors and benzoate preservatives, as they have been…
M Michael Greger Video Summary · April 8, 2026 View Full Protocol → Key Takeaways Limit shrimp consumption to reduce exposure to banned pesticides, flame retardants, and carcinogenic chemicals like DDT, naphthalene, and benzopyrene. Prefer wild-caught shrimp over farmed shrimp to lower the risk of antibiotic-resistant bacteria and fecal contamination. Avoid ready-to-eat shrimp as they…
D Dr. Karan Video Summary · April 20, 2026 View Full Protocol → Key Takeaways Exercise daily: Incorporate low-impact activities like swimming or walking for 30 minutes daily to reduce joint stress. Maintain a healthy weight: Shedding excess weight can significantly reduce pressure on joints and alleviate arthritis symptoms. Follow an anti-inflammatory diet: Focus on…
M Modern Healthspan Video Summary · April 8, 2026 View Full Protocol → Key Takeaways GLP-1 drugs show benefits beyond weight loss, including cardiovascular and kidney disease protection GLP-1 receptor activation may help prevent cognitive decline and neurodegenerative diseases like Alzheimer’s and Parkinson’s Weight loss effects account for less than half of GLP-1 drugs’ total…
M Modern Healthspan Video Summary · April 8, 2026 View Full Protocol → Key Takeaways Natural killer (NK) cells are primary immune defenders against senescent cells, using cytotoxic enzymes to eliminate them. NK cell function declines with age due to reduced cytotoxic enzyme production, impaired cytokine response, and senescent cell evasion tactics. Senescent cells actively…
M Matt Kaeberlein Video Summary · April 20, 2026 View Full Protocol → Key Takeaways Be cautious when interpreting epigenetic clock results, as they can vary by 5-10 years in real-world conditions. Avoid testing shortly after meals, stress, or environmental changes to reduce biological variation in results. Use epigenetic clocks primarily for research purposes, not…
