Evidence-based longevity and healthspan research
M Max Lugavere Video Summary · March 12, 2026 View Full Protocol → Key Takeaways Prioritize nutrient-dense foods during pregnancy to influence baby’s long-term metabolic health. Increase omega-3 fatty acids (wild-caught fish, algae) to support fetal brain development. Limit processed sugars to reduce risk of metabolic programming issues in offspring. Notable Quotes “What you eat…
C Conquer Aging Video Summary · May 15, 2026 View Full Protocol → Key Takeaways Experiment with in vitro parabiosis to study the effects of old and young serum/plasma on cellular aging. Focus on making young systems older to uncouple aging processes and identify key factors. Monitor epigenetic and biological aging clocks to assess the…
C Conquer Aging Video Summary · May 15, 2026 View Full Protocol → Key Takeaways Monitor your kynurenine/tryptophan ratio (KTR) – Higher KTR is linked to multiple age-related declines, especially neurodegeneration. Prioritize lowering KTR – Centenarians show better KTR profiles, suggesting it’s a key longevity marker. Watch IDO1 enzyme activity – Increased IDO1 activation raises…
C Conquer Aging Video Summary · May 15, 2026 View Full Protocol → Key Takeaways Test longevity interventions on your cells first by comparing cellular responses between high-performing (centenarian-like) and low-performing cells. Focus on resiliency genes – identify and potentially activate the 65 genes expressed in centenarians to improve cellular stress response. Measure bioelectric signaling…
R Rhonda Patrick Video Summary · March 12, 2026 View Full Protocol → Key Takeaways Increase creatine dose to 20g/day during travel or sleep deprivation for cognitive benefits. Split the 20g dose (e.g. 10g morning, 10g evening) for better absorption. Note: Effects are subtle (not stimulant-like) but noticeable for mental clarity. Supplements & Protocols Mentioned…
M Matt Kaeberlein Video Summary · March 12, 2026 View Full Protocol → Key Takeaways Participate in Longevity March Madness: Predict the outcomes of 64 longevity interventions in a single elimination tournament. Download the bracket from the OptiSpan website, fill it out, and submit your predictions before March 16th. Vote for your favorite interventions through…
M Michael Greger Video Summary · May 14, 2026 View Full Protocol → Key Takeaways Get 4-7 mcg of B12 daily for optimal function (higher than the RDA of 2.4 mcg). Take 50 mcg daily or 2,000 mcg weekly – both protocols work equally well for maintaining B12 levels. For food sources: Consume B12-fortified foods…
B Bryan Johnson Video Summary · May 14, 2026 View Full Protocol → Key Takeaways Buy a HEPA air filter for each room; small units start at $50 and significantly improve air quality. Turn on your hood every time you cook to reduce exposure to carcinogenic toxins, especially during pan frying. Invest in an air…
D Dr. Karan Video Summary · May 14, 2026 View Full Protocol → Key Takeaways Eat slow-fermenting fibers like beans, whole grains, and tubers to nourish beneficial bacteria in the distal colon. Avoid relying solely on fast-fermenting fibers like inulin and oligofructose, which don’t reach the colon effectively. Diversify your fiber intake beyond common sources…
C Conquer Aging Video Summary · May 14, 2026 View Full Protocol → Key Takeaways Focus on basal mitochondrial maintenance rather than supercharging mitochondria. Maintain low resting levels of mitochondrial activity to preserve responsiveness when needed. Consider exploring GLP-1 peptides and PGC-1 alpha for influencing mitochondrial dynamics. Supplements & Protocols Mentioned GLP-1 peptides – Investigate…
D Diary of a CEO Video Summary · May 14, 2026 Key Takeaways Vote in all elections, including local ones, to counteract democratic decline. Avoid nihilism (“they’re all corrupt”)—this plays into autocrats’ hands. Monitor leadership rhetoric about press, judiciary, and civil service. True democrats respect these institutions to ensure fair future elections. Stay politically engaged—autocrats…
C Conquer Aging Video Summary · May 14, 2026 View Full Protocol → Key Takeaways Mitochondrial tuning may be key to longevity – evidence suggests turned-down mitochondria at rest reduce oxidative stress Centenarians show lower membrane potential in mitochondria when not actively needed This resting state conservation appears to create better stress management and oxidative…
