Siim Land: Good News If You Want to Megadose Creatine

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Peer-Reviewed Research
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Siim Land

Video Summary · May 29, 2026

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Key Takeaways

  • Megadose creatine at 0.2g/kg (e.g., 16g for an 80kg person) to reduce cognitive decline after severe sleep deprivation.
  • For even greater cognitive benefits under sleep deprivation, consider a higher creatine dose of 0.35g/kg (e.g., 28g for an 80kg person).
  • Use creatine primarily as a recovery aid for cognition after high stress or sleep deprivation, not as a daily brain boost.

Supplements & Protocols Mentioned

  • Creatine: Dose of 0.2g/kg (e.g., 16g for an 80kg person) for cognitive recovery after sleep deprivation.
  • Creatine: Higher dose of 0.35g/kg (e.g., 28g for an 80kg person) for enhanced cognitive benefits under sleep deprivation.

Bottom Line

Megadose creatine (16g or 28g for an 80kg person) during periods of sleep deprivation or high cognitive stress to help recover cognitive performance, but avoid relying on it for daily brain enhancement.

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Medical Disclaimer

This article is for informational purposes only and does not constitute medical advice. The research summaries presented here are based on published studies and should not be used as a substitute for professional medical consultation. Always consult a qualified healthcare provider before making any changes to your health regimen.

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