Modern Healthspan: Aging Brain Fog? Creatine’s 25g Brain Rescue | Dr Dan Pardi

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Peer-Reviewed Research
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Modern Healthspan

Video Summary · March 3, 2026

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Key Takeaways

  • Creatine (25g dose) preserves cognitive and athletic performance during severe sleep deprivation.
  • Creatine helps maintain ATP production in aging brains, supporting cognitive function.
  • Creatine supports gut health by maintaining epithelial cell integrity, reducing inflammation linked to aging.

Supplements & Protocols Mentioned

  • Creatine: 25g dose (0.35g/kg body weight) used in sleep deprivation studies.

Notable Quotes

Creatine does seem to affect these cells in a way that helps them do their job, supporting gut integrity and reducing leakiness.”

Bottom Line

Consider supplementing with creatine (25g) during sleep deprivation or as you age to support brain energy, cognitive function, and gut health.

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Medical Disclaimer

This article is for informational purposes only and does not constitute medical advice. The research summaries presented here are based on published studies and should not be used as a substitute for professional medical consultation. Always consult a qualified healthcare provider before making any changes to your health regimen.

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