Modern Healthspan: Creatine Fights Brain Aging’s Energy Crisis | Dr Dan Pardi

Key Takeaways

• Creatine supports brain energy metabolism and may combat age-related cognitive decline by improving cellular energy transfer.
• Maintain gut integrity with creatine supplementation – leaky gut accelerates aging by increasing inflammation.
• Preserve NAD+ levels through lifestyle (diet/exercise) to sustain mitochondrial function as levels drop ~50% by age 50.
• Older adults (50+) should consider creatine for cellular energy support, though more research is needed for 80+ populations.

Supplements & Protocols Mentioned

• Creatine – dosage not specified, but shown to support ATP energy transfer in aging cells.
• NAD+ boosters – maintain through exercise/diet to combat mitochondrial decline.

Notable Quotes

“Creatine facilitates energy transfer from mitochondria to sites of ATP consumption… acting like a shuttle of energy within cells.”

“When the gut doesn’t have enough energy, it gets leaky – allowing inflammatory compounds into the body.”

Bottom Line

Supplement with creatine to support brain and gut energy metabolism as you age, and prioritize lifestyle factors that maintain NAD+ levels for mitochondrial health.

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