Dr. Karan: Can DMT Help Treat Addiction in Just 15 Minutes?

ByLongevity Notes Editorial
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Peer-Reviewed Research
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Dr. Karan

Video Summary · March 27, 2026

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Key Takeaways

  • Ayahuasca has been reported to improve depression and reduce cravings/addiction in some individuals.
  • Pharmahuasca, combining monoamine oxidase inhibitors (harmine/harmaline) with DMT, is being developed for more controlled dosing.
  • Intravenous DMT has shown significant reductions in symptoms of major depressive disorder after one to two doses.
  • 5-MeO-DMT is being explored for treating alcohol addiction and depression due to its short-acting effects (about 30 minutes).
  • DMT acts as a short-acting psychedelic (lasting ~15 minutes), making it a potentially efficient option for psychiatric treatment.

Notable Quotes

“DMT is now being explored as a short-acting psychedelic, lasts about 15 minutes, can be extended if we want.”

Bottom Line

Explore emerging research on DMT and Ayahuasca as potential tools for addressing addiction and depression, particularly in controlled clinical settings.

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Medical Disclaimer

This article is for informational purposes only and does not constitute medical advice. The research summaries presented here are based on published studies and should not be used as a substitute for professional medical consultation. Always consult a qualified healthcare provider before making any changes to your health regimen.

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