Brad Stanfield: The Anti-Aging Supplement Scam (New Evidence)

Key Takeaways

• Astaxanthin showed 12% lifespan extension in male mice (ITP study), but failed at lower doses and shortened lifespan in females
• AKG (calcium alpha ketoglutarate) supplements claiming 8-year biological age reduction lack placebo-controlled evidence – epigenetic test used had 4-year margin of error
• Rapamycin is the only compound proven to extend lifespan (9% males, 14% females) in rigorous ITP testing – but it’s a prescription drug with side effects
• Avoid supplements making longevity escape velocity claims – these are marketing tactics without rigorous evidence

Supplements & Protocols Mentioned

• Astaxanthin – 4,000ppm dose tested in mice ($12/month supplement)
• AKG (Rejuvant) – $80/month supplement with unproven claims
• Nicotinamide Riboside (NR) – Failed ITP testing despite initial hype
• Resveratrol – Debunked in multiple studies (caused kidney damage in trials)
• Fisetin – No lifespan extension in ITP testing
• Fish Oil – No effect in ITP longevity studies

Notable Quotes

“The nightmare scenario has always been lifespan extension with no reduction in disability. In this study, the treated middle-aged mice got healthier over time.” – Gordon Lithgow on AKG mouse study

Bottom Line

Stick to compounds with rigorous, repeatable evidence (like rapamycin) and avoid supplements making extraordinary claims without placebo-controlled human trials. The Interventions Testing Program remains the gold standard for longevity research.

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