Matt Kaeberlein: 3HAA: The Longevity Molecule You’ve Never Heard Of

ByLongevity Notes Editorial
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Peer-Reviewed Research
M
Matt Kaeberlein

Video Summary · April 20, 2026

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Key Takeaways

  • 3HAA (3-Hydroxyanthranilic Acid) extends lifespan in worms by 25-30% and in mice by ~15%.
  • Mechanisms include improving intestinal health, enhancing microbiome interactions, and activating stress response pathways.
  • In mice, 3HAA shows sex-specific lifespan effects: males benefit more from dietary supplementation, females from genetic modulation.
  • Currently, 3HAA is not available as a supplement due to historical concerns about carcinogenicity, but those concerns have been reassessed.

Bottom Line

Continue following research on 3HAA, but avoid supplementation until further clinical studies confirm its safety and efficacy in humans.

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Medical Disclaimer

This article is for informational purposes only and does not constitute medical advice. The research summaries presented here are based on published studies and should not be used as a substitute for professional medical consultation. Always consult a qualified healthcare provider before making any changes to your health regimen.

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