Evidence-based longevity and healthspan research
D Dr. Karan Video Summary · April 1, 2026 View Full Protocol → Key Takeaways Psychedelics like psilocybin, LSD, and DMT primarily target the serotonin 2A receptor in the brain. The serotonin 2A receptor is most concentrated in the neocortex, the brain region responsible for higher-level human thinking. Unlike antidepressants (e.g., escitalopram) that target serotonin…
M Modern Healthspan Video Summary · April 1, 2026 View Full Protocol → Key Takeaways If you have APOE44 or APOE43 genotype, eat 125g (4.4oz) of unprocessed meat daily to potentially reduce Alzheimer’s risk by 55%. Avoid processed meats (salted, cured, smoked) – they increase dementia risk by 14% regardless of genotype. Prioritize beef, pork,…
B Bryan Johnson Video Summary · April 28, 2026 View Full Protocol → Key Takeaways Test your home environment for toxins like lead, mold, or chemical contaminants (especially in older properties). Replace synthetic turf/grass if present – it may contain harmful PFAS or heavy metals. Prioritize soil testing before gardening or landscaping to avoid exposure…
J John Campbell Video Summary · April 28, 2026 View Full Protocol → Key Takeaways Monitor symptoms closely after COVID vaccinations – paralysis onset occurred 36 hours after 4th Moderna dose Augmented NAC and methylene blue showed rapid improvements (within 2 days) for neurological symptoms Combine spike protein treatment (NAC/methylene blue) with neuro-regeneration therapies (microcurrent…
D Diary of a CEO Video Summary · April 28, 2026 Here’s the concise, actionable summary: Key Takeaways Aerobic exercise boosts brain-derived neurotrophic factor (BDNF) for cognitive health and neuroplasticity Strength training maintains peak muscle mass and bone density (compound lifts like deadlifts/rows recommended) Novel learning experiences (new skills/languages) build cognitive reserve and reduce Alzheimer’s…
R Rhonda Patrick Video Summary · April 28, 2026 View Full Protocol → Key Takeaways 3-minute “exercise snacks” – Do short bursts of vigorous activity (like playing with kids/pets) 3x/day (totaling 9 minutes daily). Unstructured movement counts – No gym required; daily activities with intent to move vigorously qualify. 40-50% mortality reduction – Linked to…
R Rhonda Patrick Video Summary · April 1, 2026 View Full Protocol → Key Takeaways Stop using plastic blenders – The friction from blending releases microplastics and chemicals into your food/drinks. Switch to stainless steel blenders – Specifically seek out brands that offer stainless steel blender containers to avoid plastic contamination. Prioritize this change if…
R Rhonda Patrick Video Summary · April 1, 2026 View Full Protocol → Key Takeaways Take 1g+ of omega-3 daily (women need ≥1g, men benefit from ~460mg) to slow biological aging via epigenetic changes Combine omega-3 with vitamin D (4,000 IU if deficient) for synergistic anti-aging effects – adds ~3.3 months of epigenetic age reduction…
B Ben Greenfield Video Summary · April 1, 2026 View Full Protocol → Key Takeaways 12-16 hour daily fast: Stop eating after dinner (e.g., 8 PM) and delay breakfast until 8 AM-12 PM. 24-hour fast 1-2x/month: Dinner-to-dinner fast (e.g., Saturday dinner to Sunday dinner). 3-5 day fasting-mimicking diet 4x/year: 500-800 calories/day, low protein, focus on…
S Siim Land Video Summary · April 28, 2026 View Full Protocol → Key Takeaways Maintain lean body weight in dogs to reduce risks of osteoarthritis, sarcopenia, and other obesity-related conditions. Monitor musculoskeletal health in aging dogs, especially for signs of osteoarthritis or muscle loss. Prioritize veterinary check-ups for early detection of conditions like mitral…
B Ben Greenfield Video Summary · April 1, 2026 View Full Protocol → Key Takeaways Daily intermittent fasting: Fast for 12-16 hours daily (e.g., finish dinner at 8pm, eat next at 8am). Monthly 24-hour fast: 1-2x/month, fast from dinner to dinner (e.g., Saturday dinner to Sunday dinner). Quarterly Fasting Mimicking Diet (FMD): 4x/year, do a…
M Mark Hyman Video Summary · April 1, 2026 View Full Protocol → Key Takeaways Socialize regularly – Loneliness increases dementia risk by 31%. Prioritize face-to-face connections. Adopt a Mediterranean diet – Avoid ultra-processed foods and sugar. Focus on anti-inflammatory whole foods. Prioritize 7-9 hours of sleep – Chronic sleep deprivation (
