Evidence-based longevity and healthspan research
M Matt Kaeberlein Video Summary · March 23, 2026 View Full Protocol → Key Takeaways Monitor estrogen levels during menopause, as its decline affects every cell in the body. Address symptoms systemically since estrogen loss impacts skin, joints, brain, and other tissues. Consistent hydration is crucial as estrogen loss can affect skin and mucous membranes….
D Dr. Karan Video Summary · March 23, 2026 View Full Protocol → Key Takeaways Track menstrual symptoms in detail (pain levels, duration, associated symptoms like nausea or bowel changes) to identify patterns. Advocate for diagnostic imaging if experiencing severe pelvic pain – standard ultrasounds often miss endometriosis. Seek specialists in endometriosis if dismissed by…
D Diary of a CEO Video Summary · March 23, 2026 Key Takeaways Target aging directly – Reversing aging may prevent/cure diseases like Alzheimer’s, cancer, and heart disease by restoring cellular repair mechanisms. Focus on ovarian rejuvenation – Early research shows potential to reverse infertility in aged mice by restoring egg quality (human trials pending)….
B Bryan Johnson Video Summary · March 23, 2026 View Full Protocol → Key Takeaways Prepare mentally for profound experiences by acknowledging potential loss of control. Focus on releasing tension during intense moments to avoid overwhelming distress. Embrace the sacredness of existence post-experience for a deeper sense of respect and awe. Expect difficulty in articulating…
M Modern Healthspan Video Summary · March 23, 2026 View Full Protocol → Key Takeaways Believe in improvement: Over 45% of older adults improved physical or cognitive function over 12 years, driven by positive beliefs about aging. Focus on individual progress: Avoid averages; track your own physical and cognitive trajectories. Cultivate a growth mindset: Actively…
G Gabrielle Lyon Video Summary · March 24, 2026 View Full Protocol → Key Takeaways Address metabolic health first – Fix insulin resistance and inflammation before targeting brain-specific interventions. Prioritize sleep quality – Aim for 7-9 hours of deep, uninterrupted sleep to support glymphatic system clearance. Incorporate dual-task exercises – Combine physical movement with cognitive…
B Bryan Johnson Video Summary · May 5, 2026 View Full Protocol → Key Takeaways Tirzepatide and CJC-1295 DAC are being tested in combination to cancel out side effects while retaining benefits. Tirzepatide improves metabolic function but may raise heart rate and disrupt sleep. CJC-1295 DAC boosts growth hormone/IGF-1 for repair but may cause insulin…
M Max Lugavere Video Summary · May 5, 2026 View Full Protocol → Key Takeaways Limit screen time and reduce dependency on technology to avoid mental health issues like anxiety and loss of meaning. Engage in physical labor or simulate it through activities like weightlifting or running to align with your body’s evolutionary design. Front-load…
G Gabrielle Lyon Video Summary · March 24, 2026 View Full Protocol → Key Takeaways Track financial management skills – Difficulty managing finances is an early predictor of cognitive decline. Engage in active thinking – Avoid letting technology completely replace mental processing tasks. Prioritize sleep – Consistently sleeping less than 6 hours nightly increases dementia…
M Matt Kaeberlein Video Summary · March 24, 2026 View Full Protocol → Key Takeaways Track your symptoms—understand how menopause evolves uniquely for you. Manage stress and mindset—these factors shape your menopause experience significantly. Monitor health risks—focus on preventing age-related diseases like diabetes, cardiovascular disease, and bone health issues. Seek care proactively—don’t wait until symptoms…
S Siim Land Video Summary · March 24, 2026 View Full Protocol → Key Takeaways Test for B12 deficiency if experiencing premature graying, especially if under 20 years old. Increase dietary B12 intake through meat and animal products, or consider supplements if deficient. Monitor other micronutrients like iron, zinc, magnesium, and copper, as deficiencies can…
R Rhonda Patrick Video Summary · May 5, 2026 View Full Protocol → Key Takeaways Squat test: Check if you can squat with hips below knees – if not, indicates mobility issues. Single-leg knee raise: Stand on one leg, lift other knee past 90° – most people struggle with this. Sit-and-rise test: Lower to cross-legged…
