Ben Greenfield: The NAD Mistake 99% of Biohackers Make (Molecular Biologist Explains)

ByLongevity Notes Editorial
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Peer-Reviewed Research
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Ben Greenfield

Video Summary · April 25, 2026

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Key Takeaways

  • Don’t take NAD precursors like NMN or NR alone – pair them with methylation support (e.g., TMG, folate, B12) to avoid depleting methyl groups.
  • Cycle NAD boosters – avoid continuous use to prevent potential downregulation of natural NAD production pathways.
  • Prioritize natural NAD boosters first – exercise, fasting, and sunlight exposure enhance NAD more sustainably than supplements.
  • Consider liposomal NAD+ or injections for direct NAD delivery if oral precursors aren’t effective.

Supplements & Protocols Mentioned

  • NMN (Nicotinamide Mononucleotide) – 250-500mg/day, with methyl donors.
  • NR (Nicotinamide Riboside) – 300-600mg/day, with methyl donors.
  • TMG (Trimethylglycine) – 500-1000mg/day to support methylation.
  • Liposomal NAD+ – 100-200mg/day for direct absorption.
  • NAD+ injections – clinical/administered doses (exact amount varies by provider).

Bottom Line

Optimize NAD levels by combining lifestyle strategies (exercise, fasting) with methylation-supported supplementation, and avoid long-term, unopposed NAD precursor use.

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Medical Disclaimer

This article is for informational purposes only and does not constitute medical advice. The research summaries presented here are based on published studies and should not be used as a substitute for professional medical consultation. Always consult a qualified healthcare provider before making any changes to your health regimen.

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