Modern Healthspan: Ketone Salts vs Esters vs MCT: Which Actually Fuels Ketosis? | Dr Eric Plaisance
Peer-Reviewed Research
Key Takeaways
- MCTs (medium-chain triglycerides) provide sustained ketosis for hours by rapidly converting to ketones in the liver.
- Ketone salts (bound to sodium/potassium) offer a quick 10-15 minute ketone boost but may cause GI discomfort.
- Ketone esters (like butanediol) combine rapid absorption with sustained release, ideal for both immediate and prolonged effects.
Supplements & Protocols Mentioned
- MCT oil: 15-30g dose for sustained ketosis.
- Ketone salts: Dose-dependent effects (0.5-3mmol/L ketone increase).
- Ketone esters: Bis octanoyl butanediol blends rapid and sustained ketone production (lasts ~4 hours).
Notable Quotes
“MCTs provide a sustained increase in circulating ketones for many hours after consumption.”
Bottom Line
For immediate + prolonged ketosis, use ketone esters like bis octanoyl butanediol. For steady ketosis, opt for MCT oil (15-30g). Avoid salts if GI-sensitive.
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- Modern Healthspan’s Full Protocol — supplements, dosages, and daily routine
- Compare All Protocols — side-by-side protocols
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Medical Disclaimer
This article is for informational purposes only and does not constitute medical advice. The research summaries presented here are based on published studies and should not be used as a substitute for professional medical consultation. Always consult a qualified healthcare provider before making any changes to your health regimen.
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