Conquer Aging: Ergothioneine Improves Memory, Sleep, Liver Function, And Neurodegeneration

Key Takeaways

• Ergothioneine supplementation at 25 mg/day transiently improves composite memory and enhances subjective memory and sleep quality in healthy older adults.
• Higher doses of ergothioneine (25 mg/day) improve liver function by reducing plasma AST and ALT levels.
• In older adults with mild cognitive impairment, ergothioneine (25 mg, 3x/week) improves learning ability and prevents neurodegeneration markers (NFL) over one year.
• For middle-aged adults with sleep complaints, ergothioneine (20 mg/day) reduces sleeping difficulties compared to placebo.
• Ergothioneine (8 mg/day) improves subjective sleep quality, including feelings of refreshment and sleep length, in healthy adults aged 47-60.

Supplements & Protocols Mentioned

• Ergothioneine: 10 mg/day and 25 mg/day for 16 weeks in healthy older adults.
• Ergothioneine: 25 mg, 3x/week for one year in older adults with mild cognitive impairment.
• Ergothioneine: 20 mg/day for 4 weeks in middle-aged adults with sleep complaints.
• Ergothioneine: 8 mg/day for 16 weeks in healthy adults aged 47-60.

Bottom Line

Consider supplementing with ergothioneine at doses between 8-25 mg/day to improve memory, sleep quality, and liver function, depending on your age and health status.

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