Matt Kaeberlein: Dr. Matt Ranks Longevity Supplements: The Winners and Total Scams

Key Takeaways

• Avoid fucoidin due to weak longevity evidence, extreme dosing requirements (50g/day), and potential heavy metal contamination.
• Consider lithium orotate (not prescription lithium) for potential cognitive benefits based on consistent epidemiological and preclinical data.
• Be skeptical of fisetin as a senolytic – mouse lifespan effects aren’t reproducible and human trial data remains weak.
• Steer clear of anything marketed as “anti-aging” or “Sirtuin 6 activator” supplements.

Supplements & Protocols Mentioned

• Fucoidin: Avoid (50g/day human equivalent dose is impractical)
• Lithium orotate: Potential cognitive benefits (not prescription lithium carbonate)
• Fisetin: Overhyped senolytic with unproven effects
• Sirtuin 6 activators: Avoid all supplements making this claim

Notable Quotes

“Anything that is marketed under the term anti-aging goes in the avoid category.”

“The most overhyped longevity intervention ever.” (on NAD+ supplements)

Bottom Line

Focus on supplements with strong human evidence (like lithium orotate), avoid unproven “anti-aging” products, and be highly skeptical of mouse studies that don’t translate to practical human dosing.

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