Siim Land: I Tested the $5 NAD+ Alternative – Here’s What Happened

Key Takeaways

• Niacinamide (200-500mg) raises NAD+ levels by ~10% (peaks at 12 hours), offering similar benefits to NMN/NR at 1/20th the cost.
• Take NAD+ boosters in the morning to avoid sleep disruption from increased energy.
• Prioritize NAD+ recycling via salvage pathway (supported by niacinamide) over excessive supplementation – high NAD+ can feed cancers.
• Use niacinamide situationally for jet lag recovery, sleep deprivation, or UV protection (shown to reduce skin cancer risk).

Supplements & Protocols Mentioned

• Niacinamide (200mg daily, morning) – $5-$10/month alternative to NMN/NR.
• NR (Nicotinamide Riboside) – Most studied, 2-3x NAD+ increase, but costs ~$80/month.
• NMN (Nicotinamide Mononucleotide) – 1.5-2.5x NAD+ increase, mid-range price.

Notable Quotes

“NAD isn’t a molecule that you just want to keep increasing as high as possible. It has a point of diminishing returns, and high NAD levels can also be harmful.”

Bottom Line

Try 200mg niacinamide mornings for affordable NAD+ support, especially during travel/sleep disruptions. Avoid megadoses (>500mg) and pair with lifestyle factors (exercise, circadian rhythm) for optimal NAD+ recycling.

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