Modern Healthspan: NR vs NMN vs NAM : Who Wins in Human NAD Trial?

Key Takeaways

• Nicotinamide Riboside (NR) and NMN both doubled baseline NAD levels after 14 days of daily supplementation at 1 gram per day.
• Nicotinamide did not significantly raise baseline NAD levels, despite a rapid spike in blood metabolites shortly after ingestion.
• Both NR and NMN are processed by the gut microbiome into Nicotinic Acid, which then contributes to sustained NAD production.
• NR was associated with beneficial changes in gut microbiome composition and increased short-chain fatty acid production.

Supplements & Protocols Mentioned

• Nicotinamide Riboside (NR): 1 gram per day for 14 days.
• NMN: 1 gram per day for 14 days.
• Nicotinamide: 500 milligrams per day for 14 days.

Notable Quotes

“NR and NMN don’t cause large acute spikes in the blood because much of their activity appears to happen downstream in the gut after microbial processing, resulting in a slower but more sustained contribution to circulating NAD.”

Bottom Line

For sustained NAD boosting, consider taking Nicotinamide Riboside or NMN at 1 gram daily, as they effectively raise baseline NAD levels over time through gut microbiome processing.

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