Siim Land: I Megadosed 120 mg of Melatonin
Peer-Reviewed Research
Key Takeaways
- High-dose melatonin (120 mg) may act as a powerful antioxidant and anti-inflammatory, potentially supporting longevity.
- Side effects included waking at 4 AM feeling fully rested, mild headaches, and slight daytime irritability.
- Clinical research shows benefits for dementia (sleep regulation, neuroprotection), cancer (chemo support), heart health (lower BP/cholesterol), and COVID-19 (anti-inflammatory).
- Safety appears good even at extreme doses (up to 3000 mg in studies), but more trials are needed.
Supplements & Protocols Mentioned
- Melatonin – 120 mg nightly dose (megadose), compared to typical 0.5-5 mg sleep doses.
Notable Quotes
“Melatonin is a God tier supplement.”
Bottom Line
Consider experimenting with higher-dose melatonin (10-120 mg) for potential longevity benefits, but monitor side effects like sleep disruptions or headaches. More research is needed on mega-dosing.
Explore supplements mentioned in this video
Explore More
- Siim Land’s Full Protocol — supplements, dosages, and daily routine
- Compare All Protocols — side-by-side protocols
Watch the Full Video
Medical Disclaimer
This article is for informational purposes only and does not constitute medical advice. The research summaries presented here are based on published studies and should not be used as a substitute for professional medical consultation. Always consult a qualified healthcare provider before making any changes to your health regimen.
Peer-reviewed health research, simplified. Early access findings, clinical trial alerts & regulatory news — delivered weekly.
No spam. Unsubscribe anytime. Powered by Beehiiv.
Related Research
From Our Research Network
Daily longevity researchZone2 Training
Exercise protocolsSleep Science
Sleep optimization
Part of the Evidence-Based Research Network