Modern Healthspan: A 40% Energy Rescue for the Aging Brain in Clinical Trial | Dr Stephen Cunnane

Key Takeaways

• Take 30g MCT oil daily (split into two 15g doses) to help reduce the brain energy gap in mild cognitive impairment (MCI).
• Start with 5g doses and gradually increase to 15g twice daily over 10 days to minimize gastric side effects.
• Prioritize C8 and C10 MCTs (55% C8, 35% C10) for optimal ketone production.
• Expect peak ketone benefits (40% energy gap correction) for 15-20 minutes after each dose, with sustained partial benefits.
• Monitor cognitive improvements in memory, executive function, and language as potential indicators of efficacy.

Supplements & Protocols Mentioned

• MCT oil: 30g/day (15g at breakfast, 15g at supper), emulsified in 250ml low-fat milk.
• Optimal MCT ratio: 55% C8 (caprylic acid), 35% C10 (capric acid).

Notable Quotes

“We improved the brain energy gap by about 30 to 40% at peak ketone levels.”

“The improvement in cognitive outcomes was positively related to how much we reduced the brain energy gap.”

Bottom Line

For mild cognitive impairment, take 30g of C8/C10 MCT oil daily (split into two doses) to potentially improve brain energy metabolism and cognitive function.

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