Brad Stanfield: We Spent $724,637 Testing Rapamycin

Key Takeaways

• Combine rapamycin with exercise to potentially improve muscle function in older adults, based on a 12-week clinical trial.
• Use a cycling protocol: Take rapamycin on rest days (e.g., day six) to allow mTORC1 inhibition and autophagy, then exercise on active days.
• Focus on functional muscle tests like the 30-second chair stand test to measure improvements in strength and power.
• Ensure adherence to both exercise and supplement protocols for best results, as stricter adherence correlated with better outcomes.

Supplements & Protocols Mentioned

• Rapamycin (Sirolimus): 6 mg dose taken on rest days (day six) in a 12-week trial.
• Exercise protocol: Moderate-intensity cycling at home, performed on days one, three, and five.

Products & Gear Mentioned

• Exercycle bikes delivered to participants’ homes for safe, accessible exercise.

Notable Quotes

“Rapamycin is our best shot on goal if we want to pick a single drug to look at in the context of biological aging in humans.” – Matt Kaeberlein

Bottom Line

Consider a structured combination of rapamycin and moderate exercise, using a cycling protocol, to potentially enhance muscle function in aging populations.

Watch the Full Video