Active Clinical Trials — Longevity Supplements

Live registry of ongoing human clinical trials for the supplements covered in our protocol pages — pulled from ClinicalTrials.gov.

Last updated: March 2026

⚠️ Clinical trials listed here are for informational purposes only. Enrolment status, criteria, and results change frequently — always verify at ClinicalTrials.gov before making any decisions.

185 healthy adults aged 50–85. Rapamycin 5 or 10 mg weekly vs placebo for 1 year. First major RCT of rapamycin in non-transplant humans for longevity. Mixed results on safety/healthspan metrics after 1 year.

NCT04488601 → ClinicalTrials.gov

3,000 non-diabetic participants aged 65–79. First FDA-approved trial treating “aging” as a condition. Metformin 1,500 mg/day vs placebo. Primary endpoint: composite of age-related conditions (cancer, cardiovascular, dementia, mortality). Estimated completion 2027.

NCT02432287 → ClinicalTrials.gov

108 healthy men aged 40–60. NMN 250 mg/day for 12 weeks. Significant increase in blood NAD+ levels; modest improvements in muscle strength and walking speed. No serious adverse events. Published in GeroScience.

NCT03151239 → ClinicalTrials.gov

120 healthy adults. Nicotinamide Riboside (NR) 300 mg and 1,000 mg/day vs placebo. Dose-dependent increase in whole blood NAD+. First human RCT confirming NR raises NAD+. Published in Nature Communications.

NCT02831283 → ClinicalTrials.gov

2,157 European adults aged 70+. Omega-3 1g/day + vitamin D 2,000 IU + exercise vs placebo combinations for 3 years. Individually and combined, interventions slowed biological aging on epigenetic clocks. Published in Nature Aging, 2025.

NCT02166216 → ClinicalTrials.gov

Intermittent dosing of D+Q senolytic combination in Alzheimer’s patients. Reducing senescent cell burden as potential neuroprotective strategy. Estimated completion 2026.

NCT04685590 → ClinicalTrials.gov

100 older adults with subjective cognitive decline. Spermidine-rich plant extract 3 months. Improved mnemonic discrimination capacity vs placebo. Published in Alzheimer’s & Dementia: Translational Research.

NCT03094546 → ClinicalTrials.gov

How to search for more trials: Visit ClinicalTrials.gov and filter by: Condition = “aging” OR specific compound name · Status = Recruiting or Active. For animal/preclinical data, PubMed Central is the best source.

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