Longevity Protocol Comparison: 12 Experts, Side by Side

Longevity Protocol Comparison: 12 Experts, Side by Side

How Attia, Huberman, Sinclair, Brecka, Johnson, Patrick, Diamandis, Kaeberlein, Hyman, and Stanfield compare on every major supplement and intervention — ranked by consensus.

Last updated: March 2026 · 35+ supplements analyzed · 12 experts compared

Universal
Majority
Minority
Prescription
✅ Takes · — Doesn’t · 🔄 Stopped
Compound # Evidence Attia Huberman Sinclair Brecka Johnson Patrick Diamandis Kaeberlein Hyman Stanfield S. Land Lyon
Omega-3 Fish Oil
2-4g EPA+DHA		 12/12 ⭐⭐⭐⭐⭐ ✅ ✅ ✅ ✅ ✅ ✅ ✅ ✅ ✅ ✅ ✅ ✅
Vitamin D3
2,000-6,000 IU		 11/12 ⭐⭐⭐⭐⭐ ✅ ✅ ✅ ✅ ✅ ✅ ✅ ✅ ✅ — ✅ ✅
Multivitamin
1-2 caps/day		 6/12 ⭐⭐⭐⭐ — ✅ — ✅ ✅ ✅ — — ✅ ✅ — —
Magnesium
120-400mg		 8/12 ⭐⭐⭐⭐⭐ ✅ ✅ — ✅ ✅ ✅ — — ✅ — ✅ ✅
CoQ10 / Ubiquinol
100-200mg		 5/12 ⭐⭐⭐⭐ — — — ✅ ✅ ✅ ✅ — ✅ — — —
Creatine
5g/day		 6/12 ⭐⭐⭐⭐⭐ — ✅ — — — ✅ — ✅ — ✅ ✅ ✅
NMN / NR (NAD+)
250-1000mg		 4/12 ⭐⭐⭐ — — ✅ — ✅ — ✅ — ✅ — — —
Rapamycin
Weekly low-dose		 4/12 ⭐⭐⭐⭐ ✅ — ✅ — 🔄 — ✅ ✅ — — — —
Vitamin K2
100mcg MK-7		 3/12 ⭐⭐⭐⭐ ✅ — — — — ✅ — — ✅ — — —
B Vitamins
Complex		 3/12 ⭐⭐⭐⭐ — — — ✅ — — — ✅ ✅ — — —
Statin
Varies		 3/12 ⭐⭐⭐⭐⭐ ✅ — ✅ — — — — — — ✅ — —
Sulforaphane
15-20mg		 2/12 ⭐⭐⭐⭐ — — — — — ✅ — — ✅ — — —
Melatonin
0.3-10mg		 2/12 ⭐⭐⭐⭐ — — — — — ✅ — — — ✅ — —
Metformin
500-1500mg		 2/12 ⭐⭐⭐ ✅ — 🔄 — — — ✅ — — 🔄 — —

Key Insights

  • Universal agreement: Omega-3 fish oil is the only supplement all 12 experts take. Vitamin D3 is taken by 11/12.
  • The supplement skeptics: Kaeberlein (4 supplements) and Stanfield (3 core) take the least — both are practicing researchers who view most longevity supplements as overhyped.
  • The maximalists: Johnson (~100 daily pills) and Sinclair (15+ compounds) take the most aggressive stacks.
  • Rapamycin divide: 4/12 experts take it (Attia, Sinclair, Diamandis, Kaeberlein). Johnson stopped it. Stanfield is running a trial but won’t take it outside clinical settings.
  • NMN/NR split: Only 4/12 take NAD+ boosters (Sinclair, Johnson, Diamandis, Hyman). Kaeberlein and Stanfield explicitly reject them for insufficient human evidence.
  • Metformin exodus: Once widely taken, 2 experts have stopped (Sinclair switched to berberine, Stanfield stopped over exercise-blunting concerns). Only 2 still take it (Attia, Diamandis).
  • Creatine rising: 6/12 now take it (Huberman, Patrick, Kaeberlein, Stanfield, Land, Lyon) — all citing emerging cognitive benefits, not just muscle.

Individual Protocol Pages

— —