Rhonda Patrick: The best time of day to take your fish oil

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Peer-Reviewed Research
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Rhonda Patrick

Video Summary · February 8, 2026

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Key Takeaways

  • Take omega-3 fish oil with meals to blunt post-meal inflammation caused by digestion
  • Consider taking with both meals if consuming multiple doses, as all meals cause temporary gut stress
  • Omega-3s specifically reduce LPS release, a key driver of meal-induced inflammation

Notable Quotes

“Even you could be eating the healthiest meal ever, you’re going to get a postprandial inflammatory effect because food is hard on the gut.”

Bottom Line

Take your fish oil with meals to counteract the inevitable inflammatory effects of digestion, especially targeting LPS-related gut stress.

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Medical Disclaimer

This article is for informational purposes only and does not constitute medical advice. The research summaries presented here are based on published studies and should not be used as a substitute for professional medical consultation. Always consult a qualified healthcare provider before making any changes to your health regimen.

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