Dr. Karan: Not All Women Absorb Hormones the Same

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Peer-Reviewed Research
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Dr. Karan

Video Summary · May 3, 2026

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Key Takeaways

  • Try different hormone delivery methods – If transdermal patches aren’t working (20% of patients), switch to gels or vice versa
  • Adjust dosage based on symptoms – If standard doses aren’t effective, increase estradiol dose (e.g., from 100 to 200 micrograms)
  • Monitor symptom changes – Track improvements in night sweats, migraines, and joint pain as indicators of proper absorption

Notable Quotes

“About 20% of our patients, they’re still having symptoms, and their estradiol level is low. You can either change their formulation… or increase the dose.”

Bottom Line

If standard hormone therapy isn’t working, experiment with different delivery methods (patches vs gels) and don’t hesitate to increase dosage under medical supervision – symptom relief can occur within days.

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Medical Disclaimer

This article is for informational purposes only and does not constitute medical advice. The research summaries presented here are based on published studies and should not be used as a substitute for professional medical consultation. Always consult a qualified healthcare provider before making any changes to your health regimen.

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