Rhonda Patrick: The biggest thing draining your NAD levels

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Peer-Reviewed Research
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Rhonda Patrick

Video Summary · February 16, 2026

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Key Takeaways

  • Reduce chronic inflammation – Address obesity, stress, alcohol, or other lifestyle factors draining NAD levels.
  • Prioritize weight loss if obese – High-fat diets and insulin resistance disrupt NAD metabolism.
  • Manage stress – Chronic stress increases inflammation, accelerating NAD depletion.

Bottom Line

Focus on eliminating sources of chronic inflammation (obesity, stress, poor diet) to preserve NAD levels—this has more impact than supplements alone.

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Medical Disclaimer

This article is for informational purposes only and does not constitute medical advice. The research summaries presented here are based on published studies and should not be used as a substitute for professional medical consultation. Always consult a qualified healthcare provider before making any changes to your health regimen.

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