Siim Land: Scientist Tested 10,000 Molecules to See Which One Extends Lifespan

Key Takeaways

• Rapamycin shows lifespan extension potential in multiple studies – consider low-dose intermittent protocols (e.g. 5mg weekly)
• NR/NMN (Nicotinamide Riboside/Nicotinamide Mononucleotide) boost NAD+ levels – take 250-500mg daily with food
• Fisetin acts as a senolytic – cycle 100-200mg twice yearly for 2-3 day periods
• Prioritize compounds with human clinical data over theoretical mechanisms

Supplements & Protocols Mentioned

• Rapamycin: 5-10mg weekly, monitor blood glucose and immune markers
• NR/NMN: 250-500mg daily with meals, combine with TMG (trimethylglycine) 500mg
• Fisetin: 100-200mg/day for 2-3 days quarterly, take with healthy fats
• Metformin: 500mg daily (consider only for glucose management, not longevity)

Notable Quotes

“The molecules that actually move the needle in human lifespan are far fewer than those showing promise in mice – focus on clinical evidence first.”

Bottom Line

Start with NAD+ boosters (NR/NMN) and consider adding rapamycin under medical supervision. Use fisetin quarterly for cellular cleanup.

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