Bryan Johnson: I Did Mushrooms for Science, Pt. 1

Key Takeaways

• Measure biomarkers before/after psychedelics: Bryan tracked 249 biomarkers (blood, brain activity, cortisol) to assess psilocybin’s effects on longevity.
• Use brain-monitoring wearables: He wore Colonel Flow (a brain scanner helmet) daily pre/post-trip to track neural changes during the 5g mushroom dose.
• Prepare for intensity: High-dose psilocybin (5g) is unpredictable—Bryan noted concerns about potential long-term mental shifts or loss of motivation post-trip.

Products & Gear Mentioned

• Colonel Flow: Wearable brain scanner helmet measuring vascular/neural activity (used pre, during, and post-psilocybin).
• Blueprint Advanced blood panel: 6-page biomarker panel tracked pre/post-experiment.

Notable Quotes

“This most likely is the most measured psychedelic trip in the history of the human race.”

“Everybody is unquestionably confident that I’m going to emerge as a different human.”

Bottom Line

If experimenting with psychedelics for longevity, rigorously measure biomarkers and brain activity—but approach high doses (5g+) with extreme caution due to unpredictable psychological effects.

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